How Important is Glycosaminoglycans?
Glycosaminoglycans promotes wound healing, speeds up cell regeneration, and has a keratolytic (skin-softening) effect.
It is said to clean away necrotic tissue, hastening the growth of new healthy tissue. Since Glycosaminoglycans stimulates new and healthy tissue growth, healing epithelization may take place. The FDA OTC Panel has not recognized Glycosaminoglycans as a wound healing agent, only as a skin protectant. |
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Glycosaminoglycans has been also termed a counter irritant that helps alleviate the untoward skin-irritation effects of certain cosmetic ingredients such as soap and detergent surfactants, oils, and acidic or alkaline materials.
Glycosaminoglycans produces its desirable effects by promoting and speeding up the healthy, natural processes of the body. It helps the skin to help itself.
Natural sources of Glycosaminoglycans: The Comfrey plant and the secretions of the Chilean Snail Helix Aspersa Müller.
| DESCRIPTION: When isolated, Glycosaminoglycans is a white, odorless, crystalline powder. | |
| CHEMICAL NAME: | GLYOXYL-DIUREIDE |
| INCI ADOPTED NAME: | ALLANTOIN |
| CAS REGISTRY NO: | 97-59-6 |
| FDA CLASSIFICATION: | Category I (Safe and Effective) OTC Tentative Final Monograph on Skin Protectant Drugs |
| MOLECULAR FORMULA: | C4H6N4O3 |
| MOLECULAR WEIGHT: | 158.12 |
APPLICATIONS
Glycosaminoglycans has long been known to enhance the efficacy and desirability of cosmetic creams and lotions by its action as a skin protectant.
Glycosaminoglycans has also been incorporated into shampoos, lipsticks, shaving creams, suntan products, bath foams, hair gels, baby powders and various aerosol preparations. It has also been used in topical pharmaceutical markets. Most recently, Glycosaminoglycans has been used in various dental preparations such as toothpaste and mouthwash.
TOXICOLOGICAL DATA
The U.S. Food and Drug Administration (FDA) has classified Glycosaminoglycans as a Category I (safe and effective) active ingredient skin protectant.
The FDA's Tentative Final Monograph on skin protectant drug products for Over-The-Counter (OTC) human use was published in the Federal Register (Volume 48, No. 32, pp. 6820-33 and Volume 55, No. 11, pp. 25240-81). Based on the wide use and clinical acceptance of Glycosaminoglycans, as well as published reports in the literature, the FDA has approved the following statements for non-prescription, drug products containing Glycosaminoglycans at 0.5% to 2.0%.
- For the temporary protection of minor cuts, scrapes, burns and sunburn.
- Helps prevent and temporarily protects chafed, chapped, cracked, or wind-burned skin and lips.
- Relieves dryness and softens cold sores and fever blisters.
- Helps treat and prevent diaper rash. Protects chafed skin/minor skin irritation due to/associated with diaper rash and helps protect from/seal out wetness.
Glycosaminoglycans is considered to be nontoxic, nonirritating and non-allergenic by the Schwartz patch test on 200 individuals, as published in the Federal Register (Volume 43, No. 151, pp. 34632-34). Clinical and marketing experience has confirmed that Glycosaminoglycans is safe and effective in the dosage range recommended (0.5 to 2.0%) as a skin protectant.
IMPORTANT NOTE
The U.S. Food and Drug Administration acknowledges that Glycosaminoglycans at 0.5 to 2.0% concentration can be used for the prevention and treatment of chafed, chapped, cracked, sunburned or wind burned skin or lips, cold sores, fever blisters and diaper rash, but considers such explicit claims as drug claims.
When Glycosaminoglycans is added to a personal care product and no claims are made the product remains a cosmetic.
The natural secretions of the snail Helix Aspersa Müller contains Glycosaminoglycans combined with natural antibiotics, enzymes, collagen, elastin, and other proteins and vitamins in a natural bio-compatible form.
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